LET’S TAKE A LOOK AT THE RESULTS

We asked and now you know: there is more to type 2 diabetes than managing A1C. Good thing JARDIANCE can significantly lower A1C for adults with type 2 diabetes——along with diet and exercise——and significantly reduce the risk of cardiovascular (CV) death for those who also have heart disease.

Want to learn more? Download the JARDIANCE brochure so you can keep the stats in your pocket.

Breakthrough CV benefit Lower A1C & blood sugar Additional benefits

Breakthrough CV benefit

For adults who have type 2 diabetes and heart disease

Living proof——JARDIANCE can help prevent CV death

All type 2 diabetes treatments lower blood sugar, but managing blood sugar alone may not be enough to significantly reduce CV risk. JARDIANCE is the first type 2 diabetes pill that goes beyond lowering A1C to help adults who have type 2 diabetes and heart disease.

In clinical studies, JARDIANCE offered this lifesaving cardiovascular benefit:

Signficantly reduced risk of CV death for adults who have type 2 diabetes and heart disease.

HOW DO WE KNOW?

We put JARDIANCE to the test in a 3-year clinical trial of over 7,000 adults with type 2 diabetes and CV disease. The people in the study were already taking common type 2 diabetes medicines and common CV medicines (statins, beta blockers, ACE inhibitors, etc).

But don’t take our word for it. The 2018 American Diabetes Association® Standards of Care recommends empagliflozin (the active ingredient in JARDIANCE) as the only pill of its kind to reduce the risk of CV death in adults with type 2 diabetes and established CV disease, when added to metformin.

See the facts for yourself.

What do you know about type 2 diabetes and CV disease?

A free 1-on-1 phone consultation can help answer that——and more. Simply sign up for My JARDIANCE Support.

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How about a few conversation starters?

If you have type 2 diabetes and CV disease, it’s a good idea to talk to your doctor about JARDIANCE. Bring these helpful talking points to your next appointment so you can easily get the conversation rolling.

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Lower A1C & blood sugar

NOW LET’S TALK LOWER A1C

After all, along with diet and exercise, JARDIANCE is proven to help adults with type 2 diabetes lower blood sugar and A1C. And, it may provide additional benefits, too——all in a single, daily pill taken in the morning.

LOWER A1C

In a 24-week study of adults with type 2 diabetes, JARDIANCE helped some people achieve an A1C of less than 7%.*

Lower blood sugar

In a 24-week study of adults with type 2 diabetes, people taking JARDIANCE alone reduced their fasting blood sugar levels (the measurement taken before breakfast) by an average of 19 or 25 points (mg/dL).

*13% of people taking placebo saw their A1C drop below 7%, compared with 38% of people taking JARDIANCE 10 mg and 39% of those taking JARDIANCE 25 mg.

Fasting blood sugar increased 12 points (mg/dL) in people taking placebo, while those taking JARDIANCE 10 mg and 25 mg saw their fasting blood sugar drop 19 and 25 points. At the beginning of the 24-week trials, patients had an average fasting blood sugar of 153 mg/dL.

How does JARDIANCE lower blood sugar?

Great question. JARDIANCE is a once-daily pill that’s part of a class of medicines that helps you remove some sugar that the body doesn’t need through urination.

So the bottom line is…
Removing some sugar can mean lower blood sugar levels, and lower blood sugar can mean lower A1C. And that——well, that’s why we’re here.

Additional benefits

But wait——there’s more

Even though JARDIANCE is not made for weight loss, it could also help some people lose some weight. In studies of adults with type 2 diabetes, people lost 2–3% of their body weight, on average.

And although not made to lower blood pressure, when JARDIANCE was used alone or with metformin, it helped some people lower systolic blood pressure (the top number of the blood pressure reading) a little bit, too.

What can JARDIANCE do? Glad you asked.

Call a Certified Diabetes Educator

Join My JARDIANCE Support——talk JARDIANCE 1-on-1 and get helpful materials delivered right to you.

Sign up now

What is JARDIANCE?

JARDIANCE is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes, and also to reduce the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease.

JARDIANCE is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

Important Safety Information

What is the most important information I should know about JARDIANCE?

JARDIANCE can cause serious side effects, including:

  • Dehydration. JARDIANCE can cause some people to have dehydration (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, light-headed, or weak, especially when you stand up. You may be at a higher risk of dehydration if you: have low blood pressure, take medicines to lower your blood pressure, including water pills (diuretics), are on a low salt diet, have kidney problems, are 65 years of age or older.
  • Ketoacidosis (increased ketones in your blood or urine). Ketoacidosis is a serious condition and may need to be treated in the hospital. Ketoacidosis may lead to death. Ketoacidosis occurs in people with type 1 diabetes and can also occur in people with type 2 diabetes taking JARDIANCE, even if blood sugar is less than 250 mg/dL. Stop taking JARDIANCE and call your doctor right away if you get any of the following symptoms, and if possible, check for ketones in your urine: nausea, vomiting, stomach-area (abdominal) pain, tiredness, or trouble breathing.
  • Serious urinary tract infections. Serious urinary tract infections can occur in people taking JARDIANCE and may lead to hospitalization. Tell your doctor if you have symptoms of a urinary tract infection such as a burning feeling when passing urine, a need to urinate often or right away, pain in the lower part of your stomach or pelvis, or blood in the urine. Sometimes people also may have a fever, back pain, nausea or vomiting.
  • Vaginal yeast infection. Women who take JARDIANCE may get vaginal yeast infections. Talk to your doctor if you experience vaginal odor, white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese), and/or vaginal itching.
  • Yeast infection of the penis. Men who take JARDIANCE may get a yeast infection of the skin around the penis, especially uncircumcised males and those with chronic infections. Talk to your doctor if you experience redness, itching or swelling of the penis, rash of the penis, foul smelling discharge from the penis, and /or pain in the skin around the penis.

Who should not take JARDIANCE?

  • Do not take JARDIANCE if you are allergic to empagliflozin or any of the ingredients in JARDIANCE.
  • Do not take JARDIANCE if you have severe kidney problems or are on dialysis.

What should I tell my doctor before using JARDIANCE?

  • Tell your doctor if you have kidney problems. Your doctor may do blood tests to check your kidneys before and during your treatment with JARDIANCE. Also tell your doctor if you have liver problems; have a history of urinary tract infections or problems with urination; are going to have surgery; are eating less due to illness, surgery, or a change in your diet; have or have had problems with your pancreas, including pancreatitis or surgery on your pancreas; drink alcohol very often, or drink a lot of alcohol in the short term (“binge” drinking); have any other medical conditions; are pregnant or plan to become pregnant. JARDIANCE may harm your unborn baby. If you become pregnant while taking JARDIANCE, tell your doctor as soon as possible. Tell your doctor if you are breastfeeding, or plan to breastfeed. JARDIANCE may pass into your breast milk and may harm your baby. Do not breastfeed while taking JARDIANCE.
  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take water pills (diuretics) or medicines that can lower your blood sugar such as insulin.

What are other possible side effects of JARDIANCE?

  • Low blood sugar (hypoglycemia): If you take JARDIANCE with another medicine that can cause low blood sugar, such as sulfonylurea or insulin, your risk of low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered. Symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, shaking or feeling jittery.
  • Kidney problems. Sudden kidney injury has happened in people taking JARDIANCE. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or being in the sun too long.
  • Allergic (hypersensitivity) reactions. Symptoms of serious allergic reactions to JARDIANCE may include: swelling of your face, lips, throat and other areas of your skin, difficulty with swallowing or breathing, raised, red areas on your skin (hives). If you any of these symptoms, stop taking JARDIANCE and contact your doctor or go to the nearest emergency room right away.
  • Increased fats in your blood (cholesterol).

The most common side effects of JARDIANCE include urinary tract infections and yeast infections in females.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

For more information, please see Prescribing Information and Patient Information.

CL-JAR-100002 12.19.17

What is JARDIANCE?

JARDIANCE is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes, and also to reduce the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease.

JARDIANCE is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

Important Safety Information

What is the most important information I should know about JARDIANCE?

JARDIANCE can cause serious side effects, including:

  • Dehydration. JARDIANCE can cause some people to have dehydration (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, light-headed, or weak, especially when you stand up. You may be at a higher risk of dehydration if you: have low blood pressure, take medicines to lower your blood pressure, including water pills (diuretics), are on a low salt diet, have kidney problems, are 65 years of age or older.
  • Ketoacidosis (increased ketones in your blood or urine). Ketoacidosis is a serious condition and may need to be treated in the hospital. Ketoacidosis may lead to death. Ketoacidosis occurs in people with type 1 diabetes and can also occur in people with type 2 diabetes taking JARDIANCE, even if blood sugar is less than 250 mg/dL. Stop taking JARDIANCE and call your doctor right away if you get any of the following symptoms, and if possible, check for ketones in your urine: nausea, vomiting, stomach-area (abdominal) pain, tiredness, or trouble breathing.
  • Serious urinary tract infections. Serious urinary tract infections can occur in people taking JARDIANCE and may lead to hospitalization. Tell your doctor if you have symptoms of a urinary tract infection such as a burning feeling when passing urine, a need to urinate often or right away, pain in the lower part of your stomach or pelvis, or blood in the urine. Sometimes people also may have a fever, back pain, nausea or vomiting.
  • Vaginal yeast infection. Women who take JARDIANCE may get vaginal yeast infections. Talk to your doctor if you experience vaginal odor, white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese), and/or vaginal itching.
  • Yeast infection of the penis. Men who take JARDIANCE may get a yeast infection of the skin around the penis, especially uncircumcised males and those with chronic infections. Talk to your doctor if you experience redness, itching or swelling of the penis, rash of the penis, foul smelling discharge from the penis, and /or pain in the skin around the penis.

Who should not take JARDIANCE?

  • Do not take JARDIANCE if you are allergic to empagliflozin or any of the ingredients in JARDIANCE.
  • Do not take JARDIANCE if you have severe kidney problems or are on dialysis.

What should I tell my doctor before using JARDIANCE?

  • Tell your doctor if you have kidney problems. Your doctor may do blood tests to check your kidneys before and during your treatment with JARDIANCE. Also tell your doctor if you have liver problems; have a history of urinary tract infections or problems with urination; are going to have surgery; are eating less due to illness, surgery, or a change in your diet; have or have had problems with your pancreas, including pancreatitis or surgery on your pancreas; drink alcohol very often, or drink a lot of alcohol in the short term (“binge” drinking); have any other medical conditions; are pregnant or plan to become pregnant. JARDIANCE may harm your unborn baby. If you become pregnant while taking JARDIANCE, tell your doctor as soon as possible. Tell your doctor if you are breastfeeding, or plan to breastfeed. JARDIANCE may pass into your breast milk and may harm your baby. Do not breastfeed while taking JARDIANCE.
  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take water pills (diuretics) or medicines that can lower your blood sugar such as insulin.

What are other possible side effects of JARDIANCE?

  • Low blood sugar (hypoglycemia): If you take JARDIANCE with another medicine that can cause low blood sugar, such as sulfonylurea or insulin, your risk of low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered. Symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, shaking or feeling jittery.
  • Kidney problems. Sudden kidney injury has happened in people taking JARDIANCE. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or being in the sun too long.
  • Allergic (hypersensitivity) reactions. Symptoms of serious allergic reactions to JARDIANCE may include: swelling of your face, lips, throat and other areas of your skin, difficulty with swallowing or breathing, raised, red areas on your skin (hives). If you any of these symptoms, stop taking JARDIANCE and contact your doctor or go to the nearest emergency room right away.
  • Increased fats in your blood (cholesterol).

The most common side effects of JARDIANCE include urinary tract infections and yeast infections in females.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

For more information, please see Prescribing Information and Patient Information.

CL-JAR-100002 12.19.17

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